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The half-life of a medication is the time it takes for your body to metabolize and excrete a drug so that half of the drug is removed from your body. Most drugs clear the system within 5 half-lives. Multiplying the half-life of a drug by 5 will give you the amount of time needed for most medications to clear the system. The half-life of baclofen is 2-4 hours; therefore, the drug should clear your system within 10-20 hours.
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