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ANSWERS: 2
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It is a common saying in the southern United States and is similar in meaning to the phrase "at the end of my rope".
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As a Southerner, I would say "end of my rope" is only close. That phrase has more to do with running out of hope. Losing one's religion has more to do with running out of patience, becoming angry, and losing that restraint with which our good religious upbringing has provided us. It would generally mean then, turning to cussin' or fightin'.
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