• Here's one look at it: 'OK, all. Eye color can change over time because of age or, unfortunately, disease. Eye disease is a cause of color change. So, ask a doctor to examine your eyes if you notice a slow loss of color. The change could be due to Fuch's heterochromic iridocyclitis, Horner's Syndrome, and pigmentary glaucoma, says Brian DeBroff, ophthalmology professor at Yale University. ' Eye:

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